Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Identifieur interne : 008777 ( Main/Exploration ); précédent : 008776; suivant : 008778Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Auteurs : Diane E. Bild ; David A. Bluemke ; Gregory L. Burke ; Robert Detrano ; Ana V. Diez Roux [États-Unis] ; Aaron R. Folsom ; Philip Greenland ; David R. Jacobsjr. ; Richard Kronmal [États-Unis] ; Kiang Liu ; Jennifer Clark Nelson [États-Unis] ; Daniel O Eary ; Mohammed F. Saad ; Steven Shea [États-Unis] ; Moyses Szklo ; Russell P. TracySource :
- American Journal of Epidemiology [ 0002-9262 ] ; 2002-11-01.
English descriptors
- KwdEn :
- Teeft :
- Angeles county, Aric, Arterial compliance, Arterial wave forms, Arterioscler thromb, Atherosclerosis, Atherosclerosis risk, Baseline, Baseline measurements, Bild, Blood institute, Blood pressure, Blood pressure index, Calcification, Cardia study, Cardiac, Cardiovascular, Cardiovascular disease, Cardiovascular disease risk factor, Cardiovascular diseases, Cardiovascular health study, Carotid, Carotid arteries, Chinese descent, Clin epidemiol, Clinical disease, Clinical events, Cohort, Common carotid artery, Communities study, Congestive heart failure, Continuous nature, Coronary, Coronary artery calcification, Coronary artery calcium, Coronary artery disease, Coronary calcification, Coronary calcium, Coronary heart disease, Coronary heart disease death, Coronary heart disease events, Coronary heart disease incidence, Curr opin lipidol, Data collection, Demographic data, Dorsalis pedis, Education institute, Electron beam, Endothelial function, Engl, Entire cohort, Epidemiol, Epidemiol study, Equal numbers, Ethnic groups, Event rate, Event rates, Examination components, Exclusion criteria, Family history, Field centers, First examination, Folsom, Forsyth county, Gender differences, General population, Heart disease, Hemostatic factors, Hispanic, Imaging, Infarction, Inflammation markers, Insulin resistance, Internal carotid artery, Investigator, Johns hopkins university, July, Life habits, Magnetic resonance imaging, Medical records, Medical systems, Mesa, Minority groups, Myocardial infarction, National heart, National institutes, Novacode criteria, Older adults, Other aspects, Participant, Pathological determinants, Physical activity, Plaque, Power prevalence, Predictive value, Pressure pulse contour analysis, Prevalence, Principal investigator, Progression, Public health, Radiology, Research group, Resonance imaging, Right carotid arteries, Risk factor, Risk factors, Risk relations, Source populations, Study centers, Subclinical, Subclinical disease, Subclinical disease measures, Subgroup, Systolic function, Tomography, Ultrasound, Unpublished data, Ventricular, Ventricular mass, Wake forest university, White subgroup.
Abstract
The Multi-Ethnic Study of Atherosclerosis was initiated in July 2000 to investigate the prevalence, correlates, and progression of subclinical cardiovascular disease (CVD) in a population-based sample of 6,500 men and women aged 45–84 years. The cohort will be selected from six US field centers. Approximately 38% of the cohort will be White, 28% African-American, 23% Hispanic, and 11% Asian (of Chinese descent). Baseline measurements will include measurement of coronary calcium using computed tomography; measurement of ventricular mass and function using cardiac magnetic resonance imaging; measurement of flow-mediated brachial artery endothelial vasodilation, carotid intimal-medial wall thickness, and distensibility of the carotid arteries using ultrasonography; measurement of peripheral vascular disease using ankle and brachial blood pressures; electrocardiography; and assessments of microalbuminuria, standard CVD risk factors, sociodemographic factors, life habits, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for use in nested case-control studies. DNA will be extracted and lymphocytes will be immortalized for genetic studies. Measurement of selected subclinical disease indicators and risk factors will be repeated for the study of progression over 7 years. Participants will be followed through 2008 for identification and characterization of CVD events, including acute myocardial infarction and other coronary heart disease, stroke, peripheral vascular disease, and congestive heart failure; therapeutic interventions for CVD; and mortality.
Url:
DOI: 10.1093/aje/kwf113
Affiliations:
- États-Unis
- Washington (État), État de New York
- New York, Seattle
- Université Columbia, Université de Washington
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Diez Roux</name><affiliation wicri:level="4"><orgName type="university">Université Columbia</orgName><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><wicri:noCountry code="subField">MN.</wicri:noCountry></affiliation></author><author><name sortKey="Greenland, Philip" sort="Greenland, Philip" uniqKey="Greenland P" first="Philip" last="Greenland">Philip Greenland</name><affiliation><wicri:noCountry code="subField">IL.</wicri:noCountry></affiliation></author><author><name sortKey="Jacobsjr, David R" sort="Jacobsjr, David R" uniqKey="Jacobsjr D" first="David R." last="Jacobsjr.">David R. 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Saad</name><affiliation><wicri:noCountry code="subField">CA.</wicri:noCountry></affiliation></author><author><name sortKey="Shea, Steven" sort="Shea, Steven" uniqKey="Shea S" first="Steven" last="Shea">Steven Shea</name><affiliation wicri:level="4"><orgName type="university">Université Columbia</orgName><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Szklo, Moyses" sort="Szklo, Moyses" uniqKey="Szklo M" first="Moyses" last="Szklo">Moyses Szklo</name><affiliation><wicri:noCountry code="subField">MD.</wicri:noCountry></affiliation></author><author><name sortKey="Tracy, Russell P" sort="Tracy, Russell P" uniqKey="Tracy R" first="Russell P." last="Tracy">Russell P. Tracy</name><affiliation><wicri:noCountry code="subField">VT.</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Epidemiology</title><title level="j" type="abbrev">Am. J. Epidemiol.</title><idno type="ISSN">0002-9262</idno><idno type="eISSN">1476-6256</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2002-11-01">2002-11-01</date><biblScope unit="volume">156</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="871">871</biblScope><biblScope unit="page" to="881">881</biblScope></imprint><idno type="ISSN">0002-9262</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9262</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbreviations: CVD, cardiovascular disease; MESA, Multi-Ethnic Study of Atherosclerosis.</term><term>cardiovascular diseases; cardiovascular system; cohort studies; coronary disease; epidemiologic methods; prospective studies</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Angeles county</term><term>Aric</term><term>Arterial compliance</term><term>Arterial wave forms</term><term>Arterioscler thromb</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Baseline</term><term>Baseline measurements</term><term>Bild</term><term>Blood institute</term><term>Blood pressure</term><term>Blood pressure index</term><term>Calcification</term><term>Cardia study</term><term>Cardiac</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular disease risk factor</term><term>Cardiovascular diseases</term><term>Cardiovascular health study</term><term>Carotid</term><term>Carotid arteries</term><term>Chinese descent</term><term>Clin epidemiol</term><term>Clinical disease</term><term>Clinical events</term><term>Cohort</term><term>Common carotid artery</term><term>Communities study</term><term>Congestive heart failure</term><term>Continuous nature</term><term>Coronary</term><term>Coronary artery calcification</term><term>Coronary artery calcium</term><term>Coronary artery disease</term><term>Coronary calcification</term><term>Coronary calcium</term><term>Coronary heart disease</term><term>Coronary heart disease death</term><term>Coronary heart disease events</term><term>Coronary heart disease incidence</term><term>Curr opin lipidol</term><term>Data collection</term><term>Demographic data</term><term>Dorsalis pedis</term><term>Education institute</term><term>Electron beam</term><term>Endothelial function</term><term>Engl</term><term>Entire cohort</term><term>Epidemiol</term><term>Epidemiol study</term><term>Equal numbers</term><term>Ethnic groups</term><term>Event rate</term><term>Event rates</term><term>Examination components</term><term>Exclusion criteria</term><term>Family history</term><term>Field centers</term><term>First examination</term><term>Folsom</term><term>Forsyth county</term><term>Gender differences</term><term>General population</term><term>Heart disease</term><term>Hemostatic factors</term><term>Hispanic</term><term>Imaging</term><term>Infarction</term><term>Inflammation markers</term><term>Insulin resistance</term><term>Internal carotid artery</term><term>Investigator</term><term>Johns hopkins university</term><term>July</term><term>Life habits</term><term>Magnetic resonance imaging</term><term>Medical records</term><term>Medical systems</term><term>Mesa</term><term>Minority groups</term><term>Myocardial infarction</term><term>National heart</term><term>National institutes</term><term>Novacode criteria</term><term>Older adults</term><term>Other aspects</term><term>Participant</term><term>Pathological determinants</term><term>Physical activity</term><term>Plaque</term><term>Power prevalence</term><term>Predictive value</term><term>Pressure pulse contour analysis</term><term>Prevalence</term><term>Principal investigator</term><term>Progression</term><term>Public health</term><term>Radiology</term><term>Research group</term><term>Resonance imaging</term><term>Right carotid arteries</term><term>Risk factor</term><term>Risk factors</term><term>Risk relations</term><term>Source populations</term><term>Study centers</term><term>Subclinical</term><term>Subclinical disease</term><term>Subclinical disease measures</term><term>Subgroup</term><term>Systolic function</term><term>Tomography</term><term>Ultrasound</term><term>Unpublished data</term><term>Ventricular</term><term>Ventricular mass</term><term>Wake forest university</term><term>White subgroup</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Multi-Ethnic Study of Atherosclerosis was initiated in July 2000 to investigate the prevalence, correlates, and progression of subclinical cardiovascular disease (CVD) in a population-based sample of 6,500 men and women aged 45–84 years. The cohort will be selected from six US field centers. Approximately 38% of the cohort will be White, 28% African-American, 23% Hispanic, and 11% Asian (of Chinese descent). Baseline measurements will include measurement of coronary calcium using computed tomography; measurement of ventricular mass and function using cardiac magnetic resonance imaging; measurement of flow-mediated brachial artery endothelial vasodilation, carotid intimal-medial wall thickness, and distensibility of the carotid arteries using ultrasonography; measurement of peripheral vascular disease using ankle and brachial blood pressures; electrocardiography; and assessments of microalbuminuria, standard CVD risk factors, sociodemographic factors, life habits, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for use in nested case-control studies. DNA will be extracted and lymphocytes will be immortalized for genetic studies. Measurement of selected subclinical disease indicators and risk factors will be repeated for the study of progression over 7 years. Participants will be followed through 2008 for identification and characterization of CVD events, including acute myocardial infarction and other coronary heart disease, stroke, peripheral vascular disease, and congestive heart failure; therapeutic interventions for CVD; and mortality.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li><li>État de New York</li></region><settlement><li>New York</li><li>Seattle</li></settlement><orgName><li>Université Columbia</li><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Bild, Diane E" sort="Bild, Diane E" uniqKey="Bild D" first="Diane E." last="Bild">Diane E. Bild</name><name sortKey="Bluemke, David A" sort="Bluemke, David A" uniqKey="Bluemke D" first="David A." last="Bluemke">David A. Bluemke</name><name sortKey="Burke, Gregory L" sort="Burke, Gregory L" uniqKey="Burke G" first="Gregory L." last="Burke">Gregory L. Burke</name><name sortKey="Detrano, Robert" sort="Detrano, Robert" uniqKey="Detrano R" first="Robert" last="Detrano">Robert Detrano</name><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><name sortKey="Greenland, Philip" sort="Greenland, Philip" uniqKey="Greenland P" first="Philip" last="Greenland">Philip Greenland</name><name sortKey="Jacobsjr, David R" sort="Jacobsjr, David R" uniqKey="Jacobsjr D" first="David R." last="Jacobsjr.">David R. Jacobsjr.</name><name sortKey="Liu, Kiang" sort="Liu, Kiang" uniqKey="Liu K" first="Kiang" last="Liu">Kiang Liu</name><name sortKey="O Eary, Daniel" sort="O Eary, Daniel" uniqKey="O Eary D" first="Daniel" last="O Eary">Daniel O Eary</name><name sortKey="Saad, Mohammed F" sort="Saad, Mohammed F" uniqKey="Saad M" first="Mohammed F." last="Saad">Mohammed F. Saad</name><name sortKey="Szklo, Moyses" sort="Szklo, Moyses" uniqKey="Szklo M" first="Moyses" last="Szklo">Moyses Szklo</name><name sortKey="Tracy, Russell P" sort="Tracy, Russell P" uniqKey="Tracy R" first="Russell P." last="Tracy">Russell P. Tracy</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Diez Roux, Ana V" sort="Diez Roux, Ana V" uniqKey="Diez Roux A" first="Ana V." last="Diez Roux">Ana V. Diez Roux</name></region><name sortKey="Kronmal, Richard" sort="Kronmal, Richard" uniqKey="Kronmal R" first="Richard" last="Kronmal">Richard Kronmal</name><name sortKey="Nelson, Jennifer Clark" sort="Nelson, Jennifer Clark" uniqKey="Nelson J" first="Jennifer Clark" last="Nelson">Jennifer Clark Nelson</name><name sortKey="Shea, Steven" sort="Shea, Steven" uniqKey="Shea S" first="Steven" last="Shea">Steven Shea</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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